PRENURON-PEA TABLET

Composition:

Each film-coated tablet contains Palmitoylethanolamide (PEA) 300 mg + Methylcobalamin IP 1500 mcg + Pregabalin 50 mg

Pack Type:

10 X 10

Short Discription:

First in India combination of PEA 300mg, Methylcobalamin 1500mcg & Pregabalin 50mg for superior relief in Sciatica & neuropathic pain.

SKU: 4350 Category: Best Biotech Tags: Best Biotech, First Time in India, Lumbar Radiculopathy, Main Division, Methylcobalamin 1500mcg, Neuro PCD Franchise, Neuropathic Pain Treatment, Ortho PCD, Palmitoylethanolamide, PEA 300mg, Pharma Franchise India, Pharma PCD, Pregabalin 50mg, PRENURON-PEA Tablets, Sciatica Pain Relief

PRENURON-PEA Tablets mark a major clinical advancement as a First-Time-in-India combination, launched under the Main Division of Best Biotech. This innovative triple-action formulation brings together Palmitoylethanolamide (PEA 300 mg), Methylcobalamin (1500 mcg), and Pregabalin (50 mg) to address complex nerve pain and neuro-inflammation through multiple biological pathways. Engineered to deliver exceptional therapeutic outcomes, PRENURON-PEA is particularly effective in managing Sciatica pain, lumbosacral radiculopathy, and severe peripheral neuropathies. While traditional regimens offer partial symptomatic relief, PRENURON-PEA targets the underlying neuro-inflammatory cascade, suppresses hyperactive pain signaling, and actively accelerates nerve fiber regeneration. This comprehensive approach provides patients with faster pain relief, improved mobility, and superior quality of life.

Palmitoylethanolamide (PEA)

An endogenous fatty acid amide with analgesic and anti-inflammatory properties.
Modulates mast cells and activates PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha).
Reduces neuroinflammation and sensitization of pain pathways.
Enhances the analgesic effect of Pregabalin.

Pregabalin

Binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system.
Reduces calcium influx into nerve terminals.
Decreases the release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine.
Effectively relieves neuropathic pain and associated symptoms.

Methylcobalamin

Active form of Vitamin B12.
Promotes myelin sheath regeneration and repair of damaged peripheral nerves.
Supports DNA synthesis and neuronal metabolism.
Improves nerve conduction and helps restore normal nerve function.

Targeted Neuro-Inflammation Control (Palmitoylethanolamide – PEA): As a naturally occurring bioactive lipid amide, PEA selectively binds to PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha) and modulates mast cell and microglial activation. It suppresses the release of pro-inflammatory cytokines around compressed or damaged spinal nerves, significantly alleviating nerve root inflammation in Sciatica.
Central Neuropathic Pain Modulation (Pregabalin): Acts as a high-affinity ligand for the α-2-λ (alpha-2-delta) subunit of voltage-gated calcium channels in central nervous system neurons. By reducing calcium influx, it decreases the release of pro-nociceptive neurotransmitters (glutamate, substance P, and CGRP), effectively calming hyper-excitable pain pathways.
Axonal Regeneration & Myelin Repair (Methylcobalamin): Serves as the active coenzyme form of Vitamin B12 essential for transmethylation and methionine synthesis. It promotes protein synthesis in nerve cells, repairs damaged myelin sheaths, and restores normal nerve conduction velocity across peripheral and spinal nerves.

Sciatica Pain & Lumbar Radiculopathy (severe nerve compression pain radiating down the leg)
Diabetic Peripheral Neuropathy (DPN)
Cervical Radiculopathy and Intervertebral Disc Prolapse Pain
Post-Herpetic Neuralgia (PHN)
Traumatic and Post-Surgical Nerve Injury Pain
Fibromyalgia and Central Sensitization Disorders
Peripheral neuropathy
Trigeminal neuralgia
Chronic neuropathic pain
Nerve compression syndromes
Burning feet syndrome
Tingling and numbness due to nerve damage

Standard Dosage: One tablet once or twice daily, or as strictly prescribed by a Neurologist, Orthopedician, or Physician.

Administration: Swallow the tablet whole with water, with or without food. Do not crush or chew. Taking it after meals may help improve gastrointestinal tolerance.

Must be taken strictly under medical supervision and diagnosis.